Greg Stephenson was born in Anderson, Indiana in 1962. After obtaining a B.S. in Chemistry from Ball State University, he earned a Ph.D. in Medicinal Chemistry from Purdue University for research of the solid-state properties of pharmaceuticals under the advisement of Professor Stephen Byrn. He subsequently joined Eli Lilly and Company in its Material Science and Physical Characterizations group in 1994.
He is currently a Research Advisor to the Preformulation Department, where he is responsible for the company’s small molecule X-ray crystallography laboratory and its Salt Screening groups. He was the recipient of Eli Lilly and Company’s Presidential Award in 1995, 1997, 2004 and 2012. He has authored more than 70 peer-reviewed journal articles, is named as co-inventor on 14 different patents, and has authored three book chapters. He was elected as a Fellow of the International Centre for Diffraction’s awards committee. He serves on the Editorial Advisor Board for The Journal of Pharmaceutical Sciences and Pharmaceutical Development and Technology and also reviews articles for numerous journals. He continues to be fascinated by the crystallization behavior of organic compounds and continues to venture into the laboratory on every possible opportunity.
Eli Lilly and Company 2013- Product Design and Developability, Research Advisor
Eli Lilly and Company 2005-2013 Preformulation Department, Research Advisor
Eli Lilly and Company 1999-2004 Research Scientist
Pharmaceutical Research and Development Division
Eli Lilly and Company 1994-1998 Senior Scientist
Pharmaceutical and Analytical Development Division
Material Science and Physical Characterizations Group
Served as the principal scientist responsible for Eli Lilly and Companies X-ray crystallography laboratory, X-ray powder diffraction laboratory, and thermal analysis laboratory. Work involves the discovery of solid-state forms of drug substances, the characterization of the different solid-state forms, and the selection of the optimal solid-dosage form based on these characteristics. Have participated as an expert witness, having set on the stand in two separate international cases involving patent infringement. Serve as corporate resource for evaluation of patent strength concerning crystalline forms. Other activities include process trouble shooting and support of stability studies.
Purdue University 1990-1994 Research Assistant
Studied under the advisement of Dr. Stephen R. Byrn,
Area of Specialization: Polymorphism and Analytical Chemistry of Pharmaceuticals
Used the combined techniques of single crystal X-ray diffraction, X-ray powder diffraction, 13C-solid-state Nuclear Magnetic Resonance, Thermal Analysis, and Moisture absorption/desorption analysis to study the solid-state behaviour of pharmaceutical substances. Investigated solid-state decomposition reactions using reverse phase HPLC.
Eli Lilly and Company 1986-1990 Associate Analytical Chemist Analytical Development Division
Analytical Chemist responsible for the X-ray Powder Diffraction and Thermal Analytical methods in Analytical Development for active pharmaceutical and formulated product development. Interacted with pharmaceutical scientists and process chemists to develop crystallization processes that targeted specific physical forms and understanding the solid-state properties of drug substances. Developed numerous analytical methods and testing procedures for the analysis of pharmaceutical substances.
Ph.D. from Purdue University, Medicinal Chemistry, 1994
Graduate Research Advisor: Dr. Stephen Byrn (now in Industrial and Physical Pharmacy)
B.S. in Chemistry from Ball State University
- Editorial Advisory Board Member for the Journal of Pharmaceutical Sciences 2004-2015
- Editorial Advisory Board Member for Pharmaceutical Development and Technology 2011-2015
- Recipient of Eli Lilly and Company’s Presidential Award in 2012.
- Recipient of Eli Lilly and Company’s Presidential Award in 2004.
- ICDD, elected Fellow by the International Committee for Diffraction Data’s Awards Committee, 2000.
- Chairman of Organic and Pharmaceutical Compound Subcommittee 1998-2004.
- Recipient of Eli Lilly and Company’s Presidential Award in 1998.
- Recipient of Eli Lilly and Company’s Presidential Award in 1997.
- Elected member of the International Centre for Diffraction Data (ICDD), 1997.
- Recipient of Eli Lilly and Company’s Presidential Award in 1995.
- United States Pharmacopeial Convention (USP) Research Fellowship 1992-1994.
- Member of Rho Chi, the national honor society for Pharmaceutical Sciences.
- Editorial Advisory Board Member for the Journal of Pharmaceutical Sciences 2004-2013
- Editorial Advisory Board Member for Pharmaceutical Development and Technology 2011-2013
- ICDD, elected Fellow by International Committee for Diffraction Data’s Awards Committee, 2000
- Chairman of Organic and Pharmaceutical Compound Subcommittee 1998-2004
- Elected member of the International Centre for Diffraction Data (ICDD), 1997
- United States Pharmacopeial Convention (USP) Research Fellowship 1992-1994
- Member of Rho Chi, the national honor society for Pharmaceutical Sciences
- Member of the American Association of Pharmaceutical Sciences
- Member of the American Crystallographic Association
Reviewer for: Crystal Growth and Design, Journal of Pharmaceutical Science, Expert Opinion on Drug and Metabolism & Toxicology, Pharmaceutical Development and Technology, Journal of Pharmaceutical and Biomedical Analysis, Pharmaceutical Research, Chemical Research in Toxicology, Pharmaceutical Development and Technology, and Molecular Pharmaceutics